Tectonin beta-propeller repeat-containing protein 2; WD repeat-containing protein KIAA0329/KIAA0297; TECPR2; KIAA0297; KIAA0329

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%, Protein G purified

Liquid

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-TECPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Probably plays a role as positive regulator of autophagy.

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Immunohistochemistry of paraffin-embedded human pancreatic cancer using MBS7049252 at dilution of 1:100

Immunofluorescent analysis of PC3 cells using MBS7049252 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

tectonin beta-propeller repeat containing 2

tectonin beta-propeller repeat-containing protein 2

Tectonin beta-propeller repeat-containing protein 2

KIAA0297; KIAA0329??[Similar Products]

TCPR2_HUMAN

The protein encoded by this gene is a member of the tectonin beta-propeller repeat-containing (TECPR) family, and contains both TECPR and tryptophan-aspartic acid repeat (WD repeat) domains. This gene has been implicated in autophagy, as reduced expression levels of this gene have been associated with impaired autophagy. Recessive mutations in this gene have been associated with a hereditary form of spastic paraparesis (HSP). HSP is characterized by progressive spasticity and paralysis of the legs. There is also some evidence linking mutations in this gene with birdshot chorioretinopathy (BSCR), which results in inflammation of the choroid and retina. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

TECPR2: Belongs to the WD repeat KIAA0329 family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 14q32.31

Molecular Function: protein binding

Disease: Spastic Paraplegia 49, Autosomal Recessive

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