Anti -CD1c (Cluster of differentiation antigen 1c, CD1c antigen, CD1c antigen c polypeptide, CD1c molecule, Cortical thymocyte antigen CD1c, Differentiation antigen CD1 alpha 3, R7, T cell surface glycoprotein CD1c) (APC)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_000001.10 (158259563..158264564). Location: 1q22-q23

Polyclonal

Goat

Recognizes human CD1c.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in saline, 0.1% sodium azide, 0.5% BSA. Labeled with APC.

May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of enzymatic activity. APC conjugates are sensitive to light.

Small volumes of anti-CD1C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD1c (Cluster of differentiation antigen 1c) is a 43kD member of the CD1 family of molecules. It is expressed by thymocytes, dendritic cells, and B cells, and exists as part of a noncovalent complex with 12kD beta 2-microglobulin. It is found in the plasma membrane and early endosomes (but not lysosomes), and is presumed to present glycolipids and acylated peptides to T cells. Mature human CD1c is a 316aa type I transmembrane glycoprotein. It contains a 285aa extracellular domain (ECD; aa18-302) plus a 10aa cytoplasmic tail. The ECD shows one Ig-like domain (aa203-296) that associates with beta 2-microglobulin, and a Tyr-Gln-Asp-Ile internalization motif in the cytoplasmic tail. There are three potential splice variants. One shows a Trp substitution for aa327-333, a second shows an eight aa substitution for aa298-333, and a third shows a 50aa substitution for aa297-333. There appears to be no direct mouse counterpart to human CD1c.

Antibodies; Abs to CD Markers

Flow Cytometry (FC/FACS)

Suitable for use in Flow Cytometry.

CD1c molecule

T-cell surface glycoprotein CD1c; OTTHUMP00000018909; OTTHUMP00000035066; CD1C antigen, c polypeptide; cortical thymocyte antigen CD1C; differentiation antigen CD1-alpha-3

T-cell surface glycoprotein CD1c

CD1C_HUMAN

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq]

CD1C: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: integral to plasma membrane; plasma membrane; endosome membrane

Molecular Function: beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding; glycolipid binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; T cell activation during immune response

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