Product Name
Actinin Alpha 1 (ACTN1), Recombinant Protein
Popular Item
Full Product Name
Recombinant Human Actinin Alpha 1
Product Synonym Names
ACTN1 Human; Actinin Alpha 1 Human Recombinant; ACTN1; Actinin; Alpha 1; Alpha-Actinin Cytoskeletal Isoform; F-Actin Cross-Linking Protein; Non-Muscle Alpha-Actinin-1; BDPLT15; Actinin 1 Smooth Muscle; Alpha-Actinin-1
Product Gene Name
ACTN1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MGSSHHHHHH SSGLVPRGSH MGSEFM DHYD SQQTNDYMQP EEDWDRDLLL DPAWEKQQRK TFTAWCNSHL RKAGTQIENI EEDFRDGLKL MLLLEVISGE RLAKPERGKM RVHKISNVNK ALDFIASKGV KLVSIGAEEI VDGNVKMTLG MIWTIILRFA IQDISVEETS AKEGLLLWCQ RKTAPYKNVN IQNFHISWKD GLGFCALIHR HRPELIDYGK LRKDDPLTNL NTAFDVAEKY LDIPKMLDAE DIVGTARPDE KAIMTYVSSF YHAF.
3D Structure
ModBase 3D Structure for P12814
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
ACTN1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10% glycerol
Physical Appearance
Sterile Filtered colorless solution
Preparation and Storage
Store at 4°C if entire vial will be used within 2-4 weeks.
Store, frozen at -20°C for longer periods of time.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of ACTN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
ACTN1 recombinant protein
Introduction: ACTN1 encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Description: ACTN1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 274 amino acids (1-249 a.a) and having a molecular mass of 31.4kDa. ACTN1 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Product Categories/Family for ACTN1 recombinant protein
RECOMBINANT & NATURAL PROTEINS
NCBI/Uniprot data below describe general gene information for ACTN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001093.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001102.3
[Other Products]
UniProt Primary Accession #
P12814
[Other Products]
UniProt Secondary Accession #
Q1HE25; Q9BTN1; B3V8S3; B4DHH3; B7TY16[Other Products]
UniProt Related Accession #
P12814[Other Products]
NCBI Official Full Name
alpha-actinin-1 isoform b
NCBI Official Synonym Full Names
actinin alpha 1
NCBI Official Symbol
ACTN1??[Similar Products]
NCBI Official Synonym Symbols
BDPLT15
??[Similar Products]
NCBI Protein Information
alpha-actinin-1
UniProt Protein Name
Alpha-actinin-1
UniProt Synonym Protein Names
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
Protein Family
Alpha-actinin
UniProt Gene Name
ACTN1??[Similar Products]
UniProt Entry Name
ACTN1_HUMAN
UniProt Comments for ACTN1
ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14q24|14q22-q24
Cellular Component: actin filament; cell projection; cytoplasm; cytosol; extracellular region; extracellular space; focal adhesion; intercellular junction; intracellular; pseudopodium; ruffle; stress fiber
Molecular Function: actin filament binding; double-stranded RNA binding; integrin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; vinculin binding
Biological Process: actin filament network formation; actin filament organization; focal adhesion formation; negative regulation of cell motility; platelet activation; platelet degranulation; platelet formation
Disease: Bleeding Disorder, Platelet-type, 15
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
