Solute carrier family 6 member 20￡?SIT1; XT3; XTRP3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

SLC6A20 Antibody detects endogenous levels of total SLC6A20

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-SLC6A20 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis SLC6A20 using K562 whole cell lysates

61,751 Da

solute carrier family 6 member 20

sodium- and chloride-dependent transporter XTRP3

Sodium- and chloride-dependent transporter XTRP3

SIT1; XT3; XTRP3??[Similar Products]

S6A20_HUMAN

Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]

SLC6A20: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. Defects in SLC6A20 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC6A20 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane

Molecular Function: amino acid transmembrane transporter activity; glycine:sodium symporter activity; protein binding

Biological Process: amino acid transport; glycine transport; proline transport; synaptic transmission, glycinergic

Disease: Hyperglycinuria; Iminoglycinuria

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