Product Name
SLC6A20, cDNA Clone
Full Product Name
SLC6A20 cDNA Clone
Product Gene Name
SLC6A20 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggagaaag cgcggccgct gtgggccaac tcgctacagt tcgtgttcgc ctgcatctcg tacgccgtgg gcctgggcaa cgtgtggcga ttcccgtacc tgtgccagat gtacggcgga ggtagtttcc tggtccccta catcatcatg cttatcgtgg agggaatgcc gctcttgtac ctggaactgg ctgtggggca gcgcatgcgg cagggcagca tcggcgcctg gaggaccatc agcccgtacc tcagtggtgt cggggtcgcc agcgtggtgg tctctttctt cctctccatg tactacaacg tcatcaacgc ctgggccttc tggtacctct tccactcctt ccaggatccc ctgccgtggt ctgtctgccc actgaatggt aaccacacgg gctacgatga ggagtgcgag aaggcgtcct ccacacagta cttctggtac aggaaaaccc tcaatatctc gccgtccctc caggagaacg ggggtgtgca gtgggagccg gcgctgtgcc tcctcctggc ctggctggtg gtgtacctgt gcatcctgcg tggcaccgag tccactggca aggtggtgta tttcacggcg tcactgccct attgcgtgct catcatctac ctcatcaggg gcctcacgct ccacggagcc accaatggcc tcatgtacat gttcactccc aagatagagc agctggccaa ccccaaggcc tggatcaatg cagccaccca gatcttcttc tcacttggcc tgggcttcgg cagcctgatc gccttcgcca gctacaatga gccatccaac aactgccaga agcacgccat catcgtgtcc ctcatcaaca gcttcacctc catatttgcc agcattgtca ccttctccat ctatggcttc aaggccacct tcaattatga aaactgcttg aagaaggtga gtctgctgct gaccaacact tttgaccttg aagatggctt tttgacagcc agcaacctgg agcaggtgaa gggctacctc gcatctgcct acccaagcaa atacagcgag atgttcccgc aaatcaaaaa ctgcagcttg gaatcggagc tagacacggc cgtccagggc actggcctgg cattcatcgt ctatacagag gccattaaaa acatggaggt gtcccagctg tggtcggtgc tctacttctt catgctgctg atgctgggca ttgggagcat gctggggaac acagcggcca tcctcacccc tctgacagac agcaagatca tctccagcca cctgcccaag gaggccatct caggtctggt gtgccttgtc aactgtgcca ttggcatggt gttcacgatg gaggctggga actactggtt tgacatattc aacgactacg cggccacact gtccctgctg ctcatcgtgc tggtggagac gattgccgtg tgctacgtgt acgggctgag gagatttgaa agtgacctta aggccatgac cggccgagct gtgagctggt actggaaggt gatgtgggct ggcgtaagcc cactgctgat tgtcagcctc tttgtcttct acctgagcga ctacatcctc acggggaccc tgaagtatca agcctgggac gcctcccagg gccagctcgt gaccaaagat tacccggcct atgcactggc tgtcatcggg ctgcttgtgg cctcctccac catgtgcatc cccctggcgg ccctggggac ttttgttcag cgtcgcctca agaggggaga cgcagacccc gtggcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC6A20 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC6A20. It may not necessarily be applicable to this product.
NCBI Accession #
BC126197
[Other Products]
UniProt Secondary Accession #
O75590; Q8TF10; Q9NPQ2; Q9NQ77; A1A4F2[Other Products]
UniProt Related Accession #
Q9NP91[Other Products]
Molecular Weight
61,751 Da
NCBI Official Full Name
Homo sapiens solute carrier family 6 (proline IMINO transporter), member 20, mRNA
NCBI Official Synonym Full Names
solute carrier family 6 member 20
NCBI Official Symbol
SLC6A20??[Similar Products]
NCBI Official Synonym Symbols
XT3; SIT1; Xtrp3
??[Similar Products]
NCBI Protein Information
sodium- and chloride-dependent transporter XTRP3
UniProt Protein Name
Sodium- and chloride-dependent transporter XTRP3
UniProt Synonym Protein Names
Sodium/imino-acid transporter 1; Solute carrier family 6 member 20; Transporter rB21A homolog
Protein Family
Sodium- and chloride-dependent transporter
UniProt Gene Name
SLC6A20??[Similar Products]
UniProt Synonym Gene Names
SIT1; XT3; XTRP3??[Similar Products]
UniProt Entry Name
S6A20_HUMAN
NCBI Summary for SLC6A20
Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC6A20
SLC6A20: Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N- methylated amino acids. Involved in the transport of glycine. Defects in SLC6A20 are a cause of hyperglycinuria (HG). It is a condition characterized by excess of glycine in the urine. In some cases it is associated with renal colic and renal oxalate stones. Defects in SLC6A20 are a cause of iminoglycinuria (IG). It is a disorder of renal tubular reabsorption of glycine and imino acids (proline and hydroxyproline), marked by excessive levels of all three substances in the urine. Haploinsufficiency of SLC6A20 combined with deficiency of the neutral amino acid transporter SLC6A19 or partially inactivating mutations in SLC36A2, is responsible for iminoglycinuria. Additional polymorphisms and mutations in SLC6A18 can contribute to the IG phenotype in some families. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: apical plasma membrane; integral to plasma membrane; plasma membrane
Molecular Function: amino acid transmembrane transporter activity; glycine:sodium symporter activity; protein binding
Biological Process: amino acid transport; glycine transport; proline transport; synaptic transmission, glycinergic
Disease: Hyperglycinuria; Iminoglycinuria
Research Articles on SLC6A20
1. SIT1, B(0)AT1 and ACE2 were co-localized in the brush-border membrane of small intestine enterocytes.
Precautions
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Disclaimer
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