Product Name
Junctophilin 3 (Jph3), Blocking Peptide
Full Product Name
Junctophilin 3 Antibody (Center) Blocking Peptide
Product Synonym Names
Junctophilin-3; JP-3; Junctophilin type 3; Jph3; Jp3
Product Gene Name
Jph3 blocking peptide
[Similar Products]
Product Synonym Gene Name
Jp3[Similar Products]
Antibody/Peptide Pairs
Junctophilin 3 peptide (MBS9224750) is used for blocking the activity of Junctophilin 3 antibody (MBS9213561)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9ET77
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the Center region of human Junctophilin 3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Note: Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane
Tissue Location
Specifically expressed in brain. Highest levels in the olfactory tubercle, caudate putamen, nucleus accumbens, hippocampal formation, piriform cortex and cerebellar cortex. Expressed in disctete neurons sites. In hippocampal formation, expressed in dendrites of hippocampal pyramidal and denate granule cells. In cerebellum, it is highly expressed in Purkinge cells, while it is weakly expressed in granular cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of Jph3 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Jph3 blocking peptide
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory.
NCBI/Uniprot data below describe general gene information for Jph3. It may not necessarily be applicable to this product.
NCBI Accession #
Q9ET77.1
[Other Products]
UniProt Primary Accession #
Q9ET77
[Other Products]
UniProt Secondary Accession #
Q3ZAS3; Q8BNM7; Q9EQZ2[Other Products]
UniProt Related Accession #
Q9ET77[Other Products]
Molecular Weight
81,229 Da
NCBI Official Full Name
Junctophilin-3
NCBI Official Synonym Full Names
junctophilin 3
NCBI Official Symbol
Jph3??[Similar Products]
NCBI Official Synonym Symbols
Jp3; JP-3
??[Similar Products]
NCBI Protein Information
junctophilin-3
UniProt Protein Name
Junctophilin-3
UniProt Synonym Protein Names
Junctophilin type 3
Protein Family
Junctophilin
UniProt Gene Name
Jph3??[Similar Products]
UniProt Synonym Gene Names
Jp3; JP-3??[Similar Products]
UniProt Entry Name
JPH3_MOUSE
UniProt Comments for Jph3
JPH3: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2). Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial ***** onset chorea and subcortical dementia that usually begin during the fourth decade of life. Belongs to the junctophilin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Endoplasmic reticulum; Membrane protein, integral
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; junctional membrane complex; plasma membrane
Molecular Function: calcium-release channel activity
Biological Process: learning; locomotion; memory; neuromuscular process controlling balance; regulation of neuronal synaptic plasticity
Research Articles on Jph3
1. Gene expression was slightly altered in the JP-3 and JP-4 Knockout cerebellum.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
