Junctophilin-3; JP-3; Junctophilin type 3; Jph3; Jp3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This Junctophilin 3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-578 amino acids from the Central region of human Junctophilin 3.

Purified Rabbit Polyclonal Antibody (Pab)

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.

Vial Concentration: 1.95 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-Jph3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilin 3 is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane.

Neuroscience

Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)

WB~~1:1000

Western blot analysis of anti-Junctophilin 3 Pab in mouse brain tissue lysates (35ug/lane). Junctophilin 3(arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human brain tissue reacted with Junctophilin 3 Antibody (Center) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

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junctophilin 3

junctophilin-3

Junctophilin-3

Jp3; JP-3??[Similar Products]

JPH3_MOUSE

JPH3: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Defects in JPH3 are the cause of Huntington disease-like type 2 (HDL2). Huntington disease (HD) is a neurodegenerative disorder resulting primarily from the loss of medium spiny projection neurons in the striatum, especially in the caudate nucleus, and, to a lesser extent, atrophy of mesencephalic and cortical structures. The typical clinical picture of HD combines familial ***** onset chorea and subcortical dementia that usually begin during the fourth decade of life. Belongs to the junctophilin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; junctional membrane complex; integral to membrane; plasma membrane

Molecular Function: calcium-release channel activity

Biological Process: learning; neuromuscular process controlling balance; locomotion; memory; regulation of neuronal synaptic plasticity

Kakizawa,S., EMBO J. 26 (7), 1924-1933 (2007)
Moriguchi,S., Proc. Natl. Acad. Sci. U.S.A. 103 (28), 10811-10816 (2006)
Nishi,M., Brain Res. Mol. Brain Res. 118 (1-2), 102-110 (2003)
Nishi,M., Biochem. Biophys. Res. Commun. 292 (2), 318-324 (2002)

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