Product Name
ATP2C1, cDNA Clone
Full Product Name
ATP2C1 cDNA Clone
Product Gene Name
ATP2C1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgaaggttg cacgttttca aaaaatacct aatggtgaaa atgagacaat gattcctgta ttgacatcaa aaaaagcaag tgaattacca gtcagtgaag ttgcaagcat tctccaagct gatcttcaga atggtctaaa caaatgtgaa gttagtcata ggcgagcctt tcatggctgg aatgagtttg atattagtga agatgagcca ctgtggaaga agtatatttc tcagtttaaa aatcccctta ttatgctgct tctggcttct gcagtcatca gtgttttaat gcatcagttt gatgatgccg tcagtatcac tgtggcaata cttatcgttg ttacagttgc ctttgttcag gaatatcgtt cagaaaaatc tcttgaagaa ttgagtaaac ttgtgccacc agaatgccat tgtgtgcgtg aaggaaaatt ggagcataca cttgcccgag acttggttcc aggtgataca gtttgccttt ctgttgggga tagagttcct gctgacttac gcttgtttga ggctgtggat ctttccattg atgagtccag cttgacaggt gagacaacgc cttgttctaa ggtgacagct cctcagccag ctgcaactaa tggagatctt gcatcgagaa gtaacattgc ctttatggga acactggtca gatgtggcaa agcaaagggt gttgtcattg gaacaggaga aaattctgaa tttggggagg tttttaaaat gatgcaagca gaagaggcac caaaaacccc tctgcagaag agcatggacc tcttaggaaa acaactttcc ttttactcct ttggtataat aggaatcatc atgttggttg gctggttact gggaaaagat atcctggaaa tgtttactat tagtgtaagt ttggctgtag cagcaattcc tgaaggtctc cccattgtgg tcacagtgac gctagctctt ggtgttatga gaatggtgaa gaaaagggcc attgtgaaaa agctgcctat tgttgaaact ctgggctgct gtaatgtgat ttgttcagat aaaactggaa cactgacgaa gaatgaaatg actgttactc acatatttac ttcagatggt ctgcatgctg aggttactgg agttggctat aatcaatttg gggaagtgat tgttgatggt gatgttgttc atggattcta taacccagct gttagcagaa ttgttgaggc gggctgtgtg tgcaatgatg ctgtaattag aaacaatact ctaatgggga agccaacaga aggggcctta attgctcttg caatgaagat gggtcttgat ggacttcaac aagactacat cagaaaagct gaataccctt ttagctctga gcaaaagtgg atggctgtta agtgtgtaca ccgaacacag caggacagac cagagatttg ttttatgaaa ggtgcttacg aacaagtaat taagtactgt actacatacc agagcaaagg gcagaccttg acacttactc agcagcagag agatgtgtac caacaagaga aggcacgcat gggctcagcg ggactcagag ttcttgcttt ggcttctggt cctgaactgg gacagctgac atttcttggc ttggtgggaa tcattgatcc acctagaact ggtgtgaaag aagctgttac aacactcatt gcctcaggag tatcaataaa aatgattact ggagattcac aggagactgc agttgcaatc gccagtcgtc tgggattgta ttccaaaact tcccagtcag tctcaggaga agaaatagat gcaatggatg ttcagcagct ttcacaaata gtaccaaagg ttgcagtatt ttacagagct agcccaaggc acaagatgaa aattattaag tcgctacaga agaacggttc agttgtagcc atgacaggag atggagtaaa tgatgcagtt gctctgaagg ctgcagacat tggagttgcg atgggccaga ctggtacaga tgtttgcaaa gaggcagcag acatgatcct agtggatgat gattttcaaa ccataatgtc tgcaatcgaa gagggtaaag ggatttataa taacattaaa aatttcgtta gattccagct gagcacgagt atagcagcat taactttaat ctcattggct acattaatga actttcctaa tcctctcaat gccatgcaga ttttgtggat caatattatt atggatggac ccccagctca gagccttgga gtagaaccag tggataaaga tgtcattcgt aaacctcctc gcaactggaa agacagcatt ttgactaaaa acttgatact taaaatactt gtttcatcaa taatcattgt ttgtgggact ttgtttgtct tctggcgtga gctacgagac aatgtgatta cacctcgaga cacaacaatg accttcacat gctttgtgtt ttttgacatg ttcaatgcac taagttccag atcccagacc aagtctgtgt ttgagattgg actctgcagt aatagaatgt tttgctatgc agttcttgga tccatcatgg gacaattact agttatttac tttcctccgc ttcagaaggt ttttcagact gagagcctaa gcatactggg tctggctctg ggagaggagt ggacagcagc tggttga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ATP2C1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ATP2C1. It may not necessarily be applicable to this product.
NCBI Accession #
BC028139
[Other Products]
UniProt Secondary Accession #
O76005; Q86V72; Q86V73; Q8N6V1; Q8NCJ7; B2RAT7; B4DSW3; B7Z3X9; G3XAH8; G8JLN9[Other Products]
UniProt Related Accession #
P98194[Other Products]
Molecular Weight
104,032 Da
NCBI Official Full Name
Homo sapiens ATPase, Ca++ transporting, type 2C, member 1, mRNA
NCBI Official Synonym Full Names
ATPase secretory pathway Ca2+ transporting 1
NCBI Official Symbol
ATP2C1??[Similar Products]
NCBI Official Synonym Symbols
HHD; BCPM; PMR1; SPCA1; hSPCA1; ATP2C1A
??[Similar Products]
NCBI Protein Information
calcium-transporting ATPase type 2C member 1
UniProt Protein Name
Calcium-transporting ATPase type 2C member 1
UniProt Synonym Protein Names
ATP-dependent Ca(2+) pump PMR1
Protein Family
Calcium-transporting ATPase
UniProt Gene Name
ATP2C1??[Similar Products]
UniProt Synonym Gene Names
KIAA1347; PMR1L; ATPase 2C1??[Similar Products]
UniProt Entry Name
AT2C1_HUMAN
NCBI Summary for ATP2C1
The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium ions. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Comments for ATP2C1
ATP2C1: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. Defects in ATP2C1 are the cause of Hailey-Hailey disease (HHD); also known as benign familial pemphigus. HHD is an autosomal dominant disorder characterized by persistent blisters and suprabasal cell separation (acantholysis) of the epidermis, due to impaired keratinocyte adhesion. Patients lacking all isoforms except isoform 2 have HHD. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Membrane protein, integral; EC 3.6.3.8; Transporter, ion channel; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 3q22.1
Cellular Component: Golgi apparatus; Golgi membrane; integral to plasma membrane; membrane; trans-Golgi network
Molecular Function: calcium-transporting ATPase activity; signal transducer activity
Biological Process: actin cytoskeleton reorganization; calcium ion transport; calcium-dependent cell-cell adhesion; cellular calcium ion homeostasis; epidermis development; Golgi calcium ion homeostasis; Golgi calcium ion transport; positive regulation of I-kappaB kinase/NF-kappaB cascade
Disease: Benign Chronic Pemphigus
Research Articles on ATP2C1
1. Besides the level of functional ATP2C1 protein, levels of other ATPase proteins may influence expressivity of the disease and may also contribute to atypical presentations in three male members of the Hailey Hailey disease family.
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Disclaimer
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