Anti -ZMPSTE24, ID (ZMPSTE24, FACE1, STE24, CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 4; NC_000070.6 (121059238..121098243, complement). Location: 4 D2.2; 4

Polyclonal

IgG

Rabbit

Human, mouse

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-Zmpste24 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

ZMPSTE24 is a zinc metalloprotease similar to yeast Ste24p. It is an integral membrane protein belonging to peptidase family M48 and is found in the endoplasmic reticulum and possibly in the Golgi compartment. It is thought to be involved in the proteolytic processing of farnesylated proteins.

Antibodies; Abs to Matrix Metalloproteinases

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

54,735 Da[Similar Products]

zinc metallopeptidase, STE24

CAAX prenyl protease 1 homolog; zinc metallopeptidase STE24; zinc metallopeptidase, STE24 homolog; zinc metalloproteinase Ste24 homolog; zinc metalloproteinase, STE24 homolog; prenyl protein-specific endoprotease 1; farnesylated proteins-converting enzyme 1; farnesylated-proteins converting enzyme 1

CAAX prenyl protease 1 homolog

Face1; FACE-1??[Similar Products]

FACE1_MOUSE

ZMPSTE24: Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. Defects in ZMPSTE24 are the cause of mandibuloacral dysplasia with type B lipodystrophy (MADB). Mandibuloacral dysplasia (MAD) is a rare autosomal recessive disorder characterized by mandibular and clavicular hypoplasia, acroosteolysis, delayed closure of the cranial suture, joint contractures, and types A or B patterns of lipodystrophy. Type B lipodystrophy observed in MADB, is characterized by generalized fat loss. Defects in ZMPSTE24 are a cause of lethal tight skin contracture syndrome (LTSCS); also called restrictive dermopathy (RD). Lethal tight skin contracture syndrome is a rare disorder mainly characterized by intrauterine growth retardation, tight and rigid skin with erosions, prominent superficial vasculature and epidermal hyperkeratosis, facial features (small mouth, small pinched nose and micrognathia), sparse/absent eyelashes and eyebrows, mineralization defects of the skull, thin dysplastic clavicles, pulmonary hypoplasia, multiple joint contractures and an early neonatal lethal course. Liveborn children usually die within the first week of life. The overall prevalence of consanguineous cases suggested an autosomal recessive inheritance. Belongs to the peptidase M48A family.

Protein type: Membrane protein, multi-pass; EC 3.4.24.84; Protease; Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; integral to membrane; nucleus

Molecular Function: peptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding; metalloendopeptidase activity

Biological Process: prenylated protein catabolic process; proteolysis; nuclear membrane organization and biogenesis

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