Full Product Name
Anti-TSC1 Antibody
Product Synonym Names
KIAA0243; TSC; Hamartin; Tuberous sclerosis 1 protein
Product Gene Name
anti-TSC1 antibody
[Similar Products]
Antibody/Peptide Pairs
TSC1 peptide (MBS8247901) is used for blocking the activity of TSC1 antibody (MBS8248189)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92574
Species Reactivity
Human, Mouse
Specificity
Recognizes endogenous levels of TSC1 protein.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human TSC1. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-TSC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TSC1 antibody
Rabbit polyclonal antibody to TSC1
Applications Tested/Suitable for anti-TSC1 antibody
Western Blot (WB)
Application Notes for anti-TSC1 antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-TSC1 antibody
Western blot analysis of TSC1 expression in NIH3T3 (A) whole cell lysates.
NCBI/Uniprot data below describe general gene information for TSC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000359.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000368.4
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UniProt Primary Accession #
Q92574
[Other Products]
UniProt Secondary Accession #
Q5VVN5; B7Z897[Other Products]
UniProt Related Accession #
Q92574[Other Products]
Molecular Weight
124,015 Da
NCBI Official Full Name
hamartin isoform 1
NCBI Official Synonym Full Names
tuberous sclerosis 1
NCBI Official Symbol
TSC1??[Similar Products]
NCBI Official Synonym Symbols
LAM; TSC
??[Similar Products]
NCBI Protein Information
hamartin
UniProt Protein Name
Hamartin
UniProt Synonym Protein Names
Tuberous sclerosis 1 protein
Protein Family
Tuberous sclerosis 1 protein
UniProt Gene Name
TSC1??[Similar Products]
UniProt Synonym Gene Names
KIAA0243; TSC??[Similar Products]
UniProt Entry Name
TSC1_HUMAN
NCBI Summary for TSC1
This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
UniProt Comments for TSC1
TSC1: tuberous sclerosis protein 1 (TSC1). May have tumor suppressor activity. Together with tuberin (TSC2), inhibits mammalian target of rapamycin (mTOR)-mediated signaling to eukaryotic initiation factor 4E-binding protein 1 (4E-BP1) and ribosomal protein S6 kinase. Regulated by the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of tuberin. Phosphorylated by cyclin-dependent kinase 1/cyclin B during the cell cycle.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: actin filament; cell cortex; cytoplasm; cytosol; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; TSC1-TSC2 complex
Molecular Function: chaperone binding; GTPase regulator activity; protein binding; protein N-terminus binding
Biological Process: ***** locomotory behavior; cell cycle arrest; cell-matrix adhesion; negative regulation of cell proliferation; negative regulation of insulin receptor signaling pathway; negative regulation of macroautophagy; negative regulation of TOR signaling pathway; negative regulation of translation; positive regulation of focal adhesion formation; protein stabilization; regulation of cell cycle; regulation of cell-matrix adhesion; regulation of phosphoprotein phosphatase activity; regulation of stress fiber formation; regulation of translation; response to insulin stimulus; rRNA export from nucleus
Disease: Focal Cortical Dysplasia Of Taylor; Lymphangioleiomyomatosis; Tuberous Sclerosis 1
Research Articles on TSC1
1. Each TBC1D7 molecule interacts simultaneously with two parallel TSC1 helices from two TSC1 molecules, suggesting that TBC1D7 may stabilize the TSC complex by tethering the C-terminal ends of two TSC1 coiled-coils.
Precautions
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Disclaimer
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