Product Name
Malcavernin (ccm2), Recombinant Protein
Full Product Name
Recombinant Danio rerio Malcavernin (ccm2)
Product Gene Name
ccm2 recombinant protein
[Similar Products]
Product Synonym Gene Name
ccm2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-455aa, full length protein
Sequence
MEEDVKKVKK PGIVSPFKRV FLKGEKGRDK KALEKSTERR ALHTFSLSLP DHRIDPDILL NDYIEKEVKY LGQLTSVPGY LNPSSRTEVL QLIDNARKSH QLAGQLTSEQ DAVVSLSAYN VKLVWRDGED IILRVPIHDI AAVSYIRDDS LHLVVLKTAQ EPGGSPCHST EMSKSPTLSS LSESGAVLVE VCCLLVLAVD NKAAAEELCL LLSQVFQIVY TESTIDFLDR AIFDGATTPT RHLSIYSEDS SSKVDVKDVF EAEASTFSFQ SSLEAGHSSS PSPTSAPASP QTKTASESEL STTAAELLQD YMTTLRTKLS SKEIQQFATL LHEYRNGASI HEFCINLRQL YGDSRKFLLL GLRPFIPEKD SQHFENFLET IGVKDGRGII TDSFGRYKRT TSSASDSTTN GNGAAGGSDE GTATSEGDEW DRMISDISND IEALGSSMDQ DGVPS
3D Structure
ModBase 3D Structure for Q6DRP4
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ccm2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ccm2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001002315.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001002315.3
[Other Products]
UniProt Primary Accession #
Q6DRP4
[Other Products]
UniProt Secondary Accession #
Q0Z802; Q568L2[Other Products]
UniProt Related Accession #
Q6DRP4[Other Products]
Molecular Weight
39,839 Da
NCBI Official Full Name
cerebral cavernous malformations protein 2 homolog
NCBI Official Synonym Full Names
cerebral cavernous malformation 2
NCBI Official Symbol
ccm2??[Similar Products]
NCBI Official Synonym Symbols
vtn; TUF2; zgc:110233
??[Similar Products]
NCBI Protein Information
cerebral cavernous malformations protein 2 homolog
UniProt Protein Name
Cerebral cavernous malformations protein 2 homolog
UniProt Synonym Protein Names
Malcavernin
Protein Family
Cerebral cavernous malformations protein
UniProt Gene Name
ccm2??[Similar Products]
UniProt Synonym Gene Names
vtn??[Similar Products]
UniProt Comments for ccm2
Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions. May also function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock ().
Research Articles on ccm2
1. These findings suggest that CCM2L and CCM2 cooperate to regulate the activity of MEKK3.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
