Full Product Name
MYL2 Antibody - middle region
Product Gene Name
anti-MYL2 antibody
[Similar Products]
Product Synonym Gene Name
MLC2; CMH10[Similar Products]
Antibody/Peptide Pairs
MYL2 peptide (MBS3245639) is used for blocking the activity of MYL2 antibody (MBS3220842)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: APKKAKKRAG GANSNVFSMF EQTQIQEFKE AFTIMDQNRD GFIDKNDLRD
3D Structure
ModBase 3D Structure for P10916
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MYL2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MYL2 antibody
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Product Categories/Family for anti-MYL2 antibody
Polyclonal;
Applications Tested/Suitable for anti-MYL2 antibody
Western Blot (WB)
Western Blot (WB) of anti-MYL2 antibody
Host: Rabbit
Target Name: MYL2
Sample Tissue: Human Stomach Tumor
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000423.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000432.3
[Other Products]
UniProt Primary Accession #
P10916
[Other Products]
UniProt Related Accession #
P10916[Other Products]
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin light chain 2
NCBI Official Symbol
MYL2??[Similar Products]
NCBI Official Synonym Symbols
MLC2; CMH10; MLC-2s/v
??[Similar Products]
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
Protein Family
Myosin regulatory
UniProt Gene Name
MYL2??[Similar Products]
UniProt Synonym Gene Names
MLC-2; MLC-2v??[Similar Products]
UniProt Entry Name
MLRV_HUMAN
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: sarcomere; cytoskeleton; myofibril; myosin complex; cytosol; A band; actin cytoskeleton
Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding
Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; post-embryonic development; muscle filament sliding; cardiac muscle contraction
Disease: Cardiomyopathy, Familial Hypertrophic, 10
Research Articles on MYL2
1. The hypocontractile activity of D94A MYL-2 mutant resulted in the rightward shift of the force-pCa dependence and decreased actin-activated myosin ATPase activity.
Precautions
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Disclaimer
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