Full Product Name
MYL2 Polyclonal Antibody
Product Synonym Names
Myosin regulatory light chain 2; ventricular/cardiac muscle isoform (MLC-2) (MLC-2v)
Product Gene Name
anti-MYL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P10916
Species Reactivity
Human, Mouse, Rat
Specificity
MYL2 Polyclonal Antibody detects endogenous levels of MYL2
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration
1 mg/ml (lot specific)
Immunogen
Synthesized peptide derived from human MYL2. at AA range: 91-140
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-MYL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MYL2 antibody
Total protein Ab
Applications Tested/Suitable for anti-MYL2 antibody
Western Blot (WB)
Application Notes for anti-MYL2 antibody
WB: 1:500-1:2000
Western Blot (WB) of anti-MYL2 antibody
Western Blot analysis of 1, mouse-heart 2, Hela cells using primary antibody diluted at 1:500 ( degree C overnight). Secondary antibody￡oGoat Anti-rabbit IgG IRDye 800 (diluted at 1:5000, 25?￡C, 1 hour)
NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000423.2
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NCBI GenBank Nucleotide #
NM_000432.3
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UniProt Primary Accession #
P10916
[Other Products]
UniProt Secondary Accession #
Q16123[Other Products]
UniProt Related Accession #
P10916[Other Products]
NCBI Official Full Name
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
NCBI Official Synonym Full Names
myosin light chain 2
NCBI Official Symbol
MYL2??[Similar Products]
NCBI Official Synonym Symbols
MLC2; CMH10; MLC-2s/v
??[Similar Products]
NCBI Protein Information
myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Protein Name
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform
UniProt Synonym Protein Names
Cardiac myosin light chain 2
Protein Family
Myosin regulatory
UniProt Gene Name
MYL2??[Similar Products]
UniProt Synonym Gene Names
MLC-2s/v??[Similar Products]
NCBI Summary for MYL2
Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
UniProt Comments for MYL2
MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: actin cytoskeleton; cytoskeleton; cytosol; myosin complex; sarcomere
Molecular Function: actin monomer binding; calcium ion binding; protein binding
Biological Process: cardiac myofibril assembly; heart contraction; heart development; muscle filament sliding; negative regulation of cell growth; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 10
Research Articles on MYL2
1. Two siblings with hypertrophic cardiomyopathy had the pathogenic variant p.Ala13Thr variant in MYL2.
Precautions
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Disclaimer
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