Product Name
DNM1L, cDNA Clone
Full Product Name
DNM1L cDNA Clone
Product Gene Name
DNM1L cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaggcgc taattcctgt cataaacaag ctccaggacg tcttcaacac ggtgggcgcc gacatcatcc agctgcctca aatcgtcgta gtgggaacgc agagcagcgg aaagagctca gtgctagaaa gcctggtggg gagggacctg cttcccagag gtactggaat tgtcacccgg agacctctca ttctgcaact ggtccatgtt tcacaagaag ataaacggaa aacaacagga gaagaaaatg gggtggaagc agaagaatgg ggtaaatttc ttcacaccaa aaataagctt tacacggatt ttgatgaaat tcgacaagaa attgaaaatg aaacagaaag aatttcagga aataataagg gagtaagccc tgaaccaatt catcttaaga ttttttcacc caacgttgtc aatttgacac ttgtggattt gccaggaatg accaaggtgc ctgtaggtga tcaacctaag gatattgagc ttcaaatcag agagctcatt cttcggttca tcagtaatcc taattccatt atcctcgctg tcactgctgc taatacagat atggcaacat cagaggcact taaaatttca agagaggtag atccagatgg tcgcagaacc ctagctgtaa tcactaaact tgatctcatg gatgcgggta ctgatgccat ggatgtattg atgggaaggg ttattccagt caaacttgga ataattggag tagttaacag gagccagcta gatattaaca acaagaagag tgtaactgat tcaatccgtg atgagtatgc ttttcttcaa aagaaatatc catctctggc caatagaaat ggaacaaagt atcttgctag gactctaaac aggttactga tgcatcacat cagagattgt ttaccagagt tgaaaacaag aataaatgtt ctagctgctc agtatcagtc tcttctaaat agctacggtg aacccgtgga tgataaaagt gctactttac tccaacttat taccaaattt gccacagaat attgtaacac tattgaagga actgcaaaat atattgaaac ttcggagcta tgcggtggtg ctagaatttg ttatattttc catgagactt ttgggcgaac cttagaatct gttgatccac ttggtggcct taacactatt gacattttga ctgccattag aaatgctact ggtcctcgtc ctgctttatt tgtgcctgag gtttcatttg agttactggt gaagcggcaa atcaaacgtc tagaagagcc cagcctccgc tgtgtggaac tggttcatga ggaaatgcaa aggatcattc agcactgtag caattacagt acacaggaat tgttacgatt tcctaaactt catgatgcca tagttgaagt ggtgacttgt cttcttcgta aaaggttgcc tgttacaaat gaaatggtcc ataacttagt ggcaattgaa ctggcttata tcaacacaaa acatccagac tttgctgatg cttgtgggct aatgaacaat aatatagagg aacaaaggag aaacaggcta gccagagaat taccttcagc tgtatcacga gacaagttaa ttcaggacag cagaagagaa actaaaaatg ttgcatctgg aggtggtggg gttggagatg gtgttcaaga accaaccaca ggcaactgga gaggaatgct gaaaacttca aaagctgaag agttattagc agaagaaaaa tcaaaaccca ttccaattat gccagccagt ccacaaaaag gtcatgccgt gaacctgcta gatgtgccag ttcctgttgc acgaaaacta tctgctcggg aacagcgaga ttgtgaggtt attgaacgac tcattaaatc atattttctc attgtcagaa agaatattca agacagtgtg ccaaaggcag taatgcattt tttggttaat catgtgaaag acactcttca gagtgagcta gtaggccagc tgtataaatc atccttattg gatgatcttc tgacagaatc tgaggacatg gcacagcgca ggaaagaagc agctgatatg ctaaaggcat tacaaggagc cagtcaaatt attgctgaaa tccgggagac tcatctttgg tga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of DNM1L cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for DNM1L. It may not necessarily be applicable to this product.
NCBI Accession #
BC024590
[Other Products]
UniProt Secondary Accession #
O14541; O60709; Q59GN9; Q7L6B3; Q8TBT7; Q9BWM1; Q9Y5J2; A8K4X9; B4DGC9; B4DSU8; J3KPI2[Other Products]
UniProt Related Accession #
O00429[Other Products]
Molecular Weight
82,057 Da
NCBI Official Full Name
Homo sapiens dynamin 1-like, mRNA
NCBI Official Synonym Full Names
dynamin 1 like
NCBI Official Symbol
DNM1L??[Similar Products]
NCBI Official Synonym Symbols
DLP1; DRP1; DVLP; EMPF; EMPF1; DYMPLE; HDYNIV
??[Similar Products]
NCBI Protein Information
dynamin-1-like protein
UniProt Protein Name
Dynamin-1-like protein
UniProt Synonym Protein Names
Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-related protein 1
Protein Family
Dynamin-1-like protein
UniProt Gene Name
DNM1L??[Similar Products]
UniProt Synonym Gene Names
DLP1; DRP1; DVLP; Dymple; HdynIV??[Similar Products]
UniProt Entry Name
DNM1L_HUMAN
NCBI Summary for DNM1L
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
UniProt Comments for DNM1L
DRP1: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis- dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport. Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Can self-assemble in multimeric ring-like structures. Interacts with BCL2L1; the interaction stimulates the GTPase activity of DMN1L in synapses and increases the number of axonal mitochondria and the size and number of synaptic vesicle clusters. Interacts with FIS1. Interacts with GSK3B and MARCH5. Interacts (via the GTPase and B domains) with UBE2I; the interaction promotes sumoylation of DNM1L, mainly in ite B domain. Interacts with PPP3CA; the interaction dephosphorylates DNM1L and regulates its transition to mitochondria. Interacts witn MID49 and MID51. Ubiquitously expressed with highest levels found in skeletal muscles, heart, kidney and brain. Isoform 1 is brain-specific. Isoform 2 and isoform 3 are predominantly expressed in testis and skeletal muscles respectively. Isoform 4 is weakly expressed in brain, heart and kidney. Isoform 5 is dominantly expressed in liver, heart and kidney. Isoform 6 is expressed in neurons. Belongs to the dynamin family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor
Chromosomal Location of Human Ortholog: 12p11.21
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; intracellular membrane-bound organelle; membrane; microtubule; mitochondrial outer membrane; mitochondrion; perinuclear region of cytoplasm; peroxisome; protein complex
Molecular Function: GTP-dependent protein binding; GTPase activator activity; GTPase activity; microtubule binding; protein binding; protein homodimerization activity; Rab GTPase binding; ubiquitin protein ligase binding
Biological Process: cell structure disassembly during apoptosis; endoplasmic reticulum organization and biogenesis; intracellular distribution of mitochondria; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrion organization and biogenesis; peroxisome fission; positive regulation of apoptosis; positive regulation of protein secretion; protein homotetramerization; protein oligomerization; regulation of protein oligomerization; release of cytochrome c from mitochondria
Disease: Encephalopathy, Lethal, Due To Defective Mitochondrial And Peroxisomal Fission
Research Articles on DNM1L
1. Haploinsufficiency of Drp1 abolished mitochondrial autophagy and exacerbated the development of heart failure.
Precautions
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Disclaimer
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