Product Name
60S ribosomal protein L11 (RL11), Recombinant Protein
Full Product Name
Recombinant Human 60S ribosomal protein L11
Product Synonym Names
CLL-associated antigen KW-12
Product Gene Name
RL11 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
Partial of the Full Length of 2-178aa, 3-178aa
3D Structure
ModBase 3D Structure for P62913
Purity/Purification
Greater than 90% as determined by SDS-PAGE.
Form/Format
20mM Tris-HCl based buffer, pH8.0
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Other Notes
Small volumes of RL11 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RL11 recombinant protein
Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML.
NCBI/Uniprot data below describe general gene information for RL11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000966.2
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NCBI GenBank Nucleotide #
NP_000966.2
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UniProt Primary Accession #
P62913
[Other Products]
UniProt Secondary Accession #
P25121; P39026; Q8TDH2; Q9Y674[Other Products]
UniProt Related Accession #
P62913[Other Products]
NCBI Official Full Name
60S ribosomal protein L11 isoform 1
NCBI Official Synonym Full Names
ribosomal protein L11
NCBI Official Symbol
RPL11??[Similar Products]
NCBI Official Synonym Symbols
L11; DBA7; GIG34
??[Similar Products]
NCBI Protein Information
60S ribosomal protein L11
UniProt Protein Name
60S ribosomal protein L11
UniProt Synonym Protein Names
CLL-associated antigen KW-12; Large ribosomal subunit protein uL5
Protein Family
60S ribosomal protein
UniProt Gene Name
RPL11??[Similar Products]
NCBI Summary for RL11
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L5P family of ribosomal proteins. It is located in the cytoplasm. The protein probably associates with the 5S rRNA. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Dec 2010]
UniProt Comments for RL11
RPL11: Binds to 5S ribosomal RNA. Required for rRNA maturation and formation of the 60S ribosomal subunits. Promotes nucleolar location of PML. Defects in RPL11 are the cause of Diamond-Blackfan anemia type 7 (DBA7). DBA7 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L5P family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: cytoplasm; cytosol; extracellular matrix; membrane; nucleolus; nucleoplasm; protein complex
Molecular Function: 5S rRNA binding; protein binding; RNA binding; structural constituent of ribosome; ubiquitin protein ligase binding
Biological Process: mRNA catabolic process, nonsense-mediated decay; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; protein stabilization; protein targeting; ribosomal large subunit assembly and maintenance; ribosomal large subunit biogenesis and assembly; rRNA processing; SRP-dependent cotranslational protein targeting to membrane; translation; translational initiation; viral transcription
Disease: Diamond-blackfan Anemia 7
Research Articles on RL11
1. Data suggest 5S ribosomal RNA is a direct target of miR-150 and miR-383 in esophageal squamous cell carcinoma (ESCC); overexpression of miR-150 and miR-383 inhibits ESCC cell proliferation in vitro and in vivo and intensifies RPL11/c-Myc interaction.
Precautions
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