Mouse Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) ELISA kit; DFNA2; DFNA2A; KV7.4; potassium channel KQT-like 4; potassium voltage-gated channel KQT-like protein 4; potassium voltage-gated channel; KQT-like subfamily; member 4

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of KCNQ4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9321474 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the potassium voltage-gated channel, KQT-like subfamily, member 4 (KCNQ4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNQ4. The ELISA analytical biochemical technique of the MBS9321474 kit is based on KCNQ4 antibody-KCNQ4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNQ4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNQ4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

77,057 Da

potassium voltage-gated channel, subfamily Q, member 4

potassium voltage-gated channel subfamily KQT member 4; KQT-like 4; potassium channel subunit alpha KvLQT4; voltage-gated potassium channel subunit Kv7.4

Potassium voltage-gated channel subfamily KQT member 4

KCNQ4_MOUSE

KCNQ4: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors. Defects in KCNQ4 are the cause of deafness autosomal dominant type 2A (DFNA2A). DFNA2A is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: voltage-gated potassium channel complex; neuron projection; membrane; cytoplasm; plasma membrane; integral to membrane

Molecular Function: voltage-gated potassium channel activity; potassium channel activity; delayed rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity

Biological Process: inner ear morphogenesis; sensory perception of sound; transport; ion transport; negative regulation of synaptic transmission, dopaminergic; transmembrane transport; potassium ion transport

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