Product Name
PRDM7, Blocking Peptide
Full Product Name
PRDM7 Peptide - N-terminal region
Product Gene Name
PRDM7 blocking peptide
[Similar Products]
PRDM7 peptide (MBS3229572) is used for blocking the activity of PRDM7 antibody (MBS3204605)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Synthetic peptide located within the following region: FIDSCAAHGP PTFVKDSAVD KGHPNRSALS LPPGLRIGPS GIPQAGLGVW
3D Structure
ModBase 3D Structure for Q9NQW5
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of PRDM7 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PRDM7 blocking peptide
This is a synthetic peptide designed for use in combination with anti-PRDM7 Antibody, made
Target Description: The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Product Categories/Family for PRDM7 blocking peptide
Peptide
Applications Tested/Suitable for PRDM7 blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PRDM7. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001091643.1
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NCBI GenBank Nucleotide #
NM_001098173.1
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UniProt Primary Accession #
Q9NQW5
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UniProt Related Accession #
Q9NQW5[Other Products]
NCBI Official Full Name
probable histone-lysine N-methyltransferase PRDM7
NCBI Official Synonym Full Names
PR/SET domain 7
NCBI Official Symbol
PRDM7??[Similar Products]
NCBI Official Synonym Symbols
PFM4; ZNF910
??[Similar Products]
NCBI Protein Information
probable histone-lysine N-methyltransferase PRDM7
UniProt Protein Name
Probable histone-lysine N-methyltransferase PRDM7
UniProt Synonym Protein Names
PR domain zinc finger protein 7; PR domain-containing protein 7
Protein Family
Probable histone-lysine N-methyltransferase
UniProt Gene Name
PRDM7??[Similar Products]
UniProt Synonym Gene Names
PFM4??[Similar Products]
NCBI Summary for PRDM7
This gene encodes a member of a family of proteins that may have roles in transcription and other nuclear processes. The encoded protein contains a KRAB (Kruppel-associated box) domain -A box and a SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain and may function as a histone methyltransferase. [provided by RefSeq, Aug 2013]
UniProt Comments for PRDM7
PRDM7: a probable histone methyltransferase. The mouse orthologous protein seems not to exist. Human PRDM7 and PRDM9 genes, a pair of close paralogs corresponding to a single mouse gene Prdm9, may have been generated by a recent gene duplication event after the divergence of the ancestors of human and mouse. Three isoforms of the human protein are produced by alternative splicing.
Protein type: EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component: chromosome; nucleus
Molecular Function: histone-lysine N-methyltransferase activity; nucleic acid binding; protein binding
Biological Process: regulation of transcription, DNA-templated
Research Articles on PRDM7
1. These studies indicate that after a single serine to tyrosine mutation at residue 357 (S357Y), PRDM7 regains the substrate specificities and catalytic activities similar to its evolutionary predecessor, including the ability to efficiently methylate H3K36.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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