PIXA; COOL2; MRX46; Cool-2; alphaPIX; alpha-PIX

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total ARHGEF6 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

2.6 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-ARHGEF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:50-1:200

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/70.

70,791 Da

Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6

rho guanine nucleotide exchange factor 6

Rho guanine nucleotide exchange factor 6

COOL2; KIAA0006; PIXA??[Similar Products]

ARHG6_HUMAN

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]

ARHGEF6: Acts as a RAC1 guanine nucleotide exchange factor (GEF). Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: Xq26.3

Cellular Component: lamellipodium; intracellular; intercellular junction; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; GTPase activator activity

Biological Process: lamellipodium biogenesis; regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of apoptosis; small GTPase mediated signal transduction; JNK cascade; positive regulation of GTPase activity

Disease: Mental Retardation, X-linked 46

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