ADAM Metallopeptidase Domain 17 (ADAM17) Antibody
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產(chǎn)品名稱: ADAM Metallopeptidase Domain 17 (ADAM17) Antibody
產(chǎn)品型號: abx000869
產(chǎn)品展商: 其他品牌
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簡單介紹
ADAM Metallopeptidase Domain 17 (ADAM17) Antibody
ADAM Metallopeptidase Domain 17 (ADAM17) Antibody
的詳細介紹
ADAM17 Antibody is a Rabbit Polyclonal antibody against ADAM17. The ADAMs (A Disintegrin And Metalloprotease) are multidomain transmembrane proteins. One of the first ADAMs implicated in membrane shedding is ADAM-17, which is shown to release the active form of tumor necrosis factor (TNF)-a from its precursor(PMID:18238782). ADAM17 is also named as CSVP, TACE. The full length protein has 9 glycosylation sites, a signal peptide, propeptide and 2 isoforms produced by alternative splicing.The 120-kDa form of ADAM-17 is expressed more frequently and at higher levels in primary breast carcinomas compared with normal breast tissue(PMID:17438092). This antibody is specific to ADAM17.
| Target |
ADAM17 |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC |
| Recommended dilutions |
WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
A synthetic peptide of human ADAM17. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 78 kDa/93 kDa
Observed MW: 115 kDa |
| Swiss Prot |
P78536
|
| GeneID |
6868
|
| Gene Symbol |
ADAM17 |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
