Adapter Molecule Crk (CRK) Antibody
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產(chǎn)品名稱: Adapter Molecule Crk (CRK) Antibody
產(chǎn)品型號(hào): abx015829
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
Adapter Molecule Crk (CRK) Antibody
的詳細(xì)介紹
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins.The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction.The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation.Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
| Target |
CRK |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, IF/ICC, FCM |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human CRK expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG2b |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
42 kDa |
| Swiss Prot |
P46108
|
| GeneID |
1398
|
| Gene Symbol |
CRK |
| OMIM |
164762
|
| HGNC |
2362 |
| Ensembl |
ENSG00000167193 |
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
