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產品名稱: Akt (pS473) Antibody
產品型號: abx010400
產品展商: 其他品牌
產品文檔: 無相關文檔
簡單介紹
Akt (pS473) Antibody
的詳細介紹
Phospho-Akt (Ser473) Antibody detects endogenous levels of Akt only when phosphorylated at Sersine 473. an AGC kinase that plays a critical role in controlling the balance between survival and AP0ptosis. Phosphorylated and activated by PDK1 in the PI3 kinase pathway. Mediates survival signals downstream of PI3 kinase and several growth factor receptors by phosphorylating AP0pototic proteins. First found in a mouse transforming retrovirus. Tumorigenic in a mouse lymphoma model and activated (by phospho-Akt staining) and/or overexpressed in a number of cancers including breast, prostate, lung, pancreatic, liver, ovarian and colorectal. Inhibitor: RX-0201. Substrates include tuberin, Bad, Forkhead transcription factors, caspase-9, and glycogen synthase kinase-3.
| Target |
Akt (pS473) |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P31749
|
| GeneID |
207
|
| Gene Symbol |
AKT1 |
| OMIM |
164730
|
| Enzyme Commission Number |
EC 2.7.11.1 |
| HGNC |
391 |
| Ensembl |
ENSG00000142208 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
