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產(chǎn)品名稱: ALOX5 (pS523) Antibody
產(chǎn)品型號: abx012014
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
ALOX5 (pS523) Antibody
的詳細(xì)介紹
Phospho-ALOX5 (Ser523) Antibody detects endogenous levels of ALOX5 only when phosphorylated at Sersine 523. This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5 (S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5 (S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
| Target |
ALOX5 (pS523) |
| Reactivity |
Human, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P09917
|
| GeneID |
240
|
| Gene Symbol |
ALOX5 |
| OMIM |
152390
|
| Enzyme Commission Number |
EC 1.13.11.34 |
| HGNC |
435 |
| Ensembl |
ENSG00000012779 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
