Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
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產(chǎn)品名稱: Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
產(chǎn)品型號: abx015770
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
Alpha-Methylacyl-CoA Racemase (AMACR) Antibody
的詳細(xì)介紹
AMACR (alpha-methylacyl-CoA racemase) has been recently described as prostate cancer-specific gene that encodes a protein involved in the beta-oxidation of branched chain fatty acids.Expression of AMACR protein is found in prostatic adenocarcinoma but not in benign prostatic tissue.It stains premalignant lesions of prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia.AMACR can be used as a positive marker for PIN.Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4); also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile.Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.
| Target |
AMACR |
| Reactivity |
Human, Mouse |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC, IF/ICC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of human AMACR expressed in E. coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG2b |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
42 kDa |
| GeneID |
23600
|
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
