CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy.

Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.

Human Platelets.

Sterile Filtered white lyophilized powder.

The CXCL4 protein was lyophilized in PBS buffer pH-7.4.

It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.

Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C.
Please prevent freeze-thaw cycles.

Greater than 95.0% as determined by:
(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.

The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu.

Binding of HIT-antibodies.

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