Biotin - anti mouse B220/CD45R - Clone RA3-3A1
如果您對(duì)該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: Biotin - anti mouse B220/CD45R - Clone RA3-3A1
產(chǎn)品型號(hào):
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
Biotin - anti mouse B220/CD45R - Clone RA3-3A1
Biotin - anti mouse B220/CD45R - Clone RA3-3A1
的詳細(xì)介紹
Biotin
- anti Mouse
B220/CD45R - RA3-3A1
| Reference |
Size |
Price |
Quantity |
Add to cart |
|
|
|
The minimum purchase order quantity for the product is 1
|
|
|
|
|
The minimum purchase order quantity for the product is 1
|
|
-
RA3-3A1
-
Rat IgG2a
-
Flow Cytometry
-
Biotin
-
0.5 mg/ml
-
Mouse cell line RAW 112
-
Mouse
-
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
-
RUO
-
-
Liquid
-
Store in the dark at 2-8 °C
View larger
CD45R antibody (clone RA3-6B2) has been reported to react with an epitope on the extracellular domain of the transmembrane CD45 glycoprotein which is dependent upon the expression of exon A and specific carbohydrate residues. It is expressed on B lymph ocytes at all stages from pro-B through mature and activated B cell, but it is decreased on plasma cells and a subset of memory B cells. The levels of CD45R expression on the B-cell lineage appear to be developmentally regulated. It is also reportedly found on the abnormal T cells involved in the lymph adenopathy of lpr/lpr and gld/gld mutant mice, on lytically active subsets of lymph okine-activated killer cells (NK cells and non-MHC-restricted CTL), on apoptotic T lymph ocytes of mice injected with bacterial superantigen, on a population of NK-cell precursors in the bone marrow, and on B-lymph ocyte, T-lymph ocyte, and macrophage progenitors in fetal liver. The CD45R antigen has been reported not to be on hematopoietic stem cells, naive T lymph ocytes, or MHC-restricted CTL. CD45 is a member of the Protein Tyrosine Phosphatase (PTP) family: Its intracellular (COOH-terminal) region contains two PTP catalytic domains, and the extracellular region is highly variable due to alternative splicing of exons 4, 5, and 6 (designated A, B, and C, respectively), plus differing levels of glycosylation. The CD45 isoforms detected in the mouse are cell type-, maturation, and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction. CD45R is commonly used as a pan B-cell marker; however, CD19 expression, detectable by CD19 antibody (clone 1D3), is reported to be more restricted to the B-cell lineage. CD45R antibody (clone RA3-6B2) has been reported to enhance isotype switching during in vitro B-cell responses and to inhibit in vivo B-cell responses. Cross-reaction of the RA3-6B2 clone with activated human T lymph ocytes has also been reportedly observed.
-
B220
-
-
180-240 kD
