GsAF-2
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
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產(chǎn)品名稱: GsAF-2
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
產(chǎn)品型號(hào): 12GSF002-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
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GsAF-2
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
的詳細(xì)介紹
GsAF-2
Blocker of Nav1.1 / 1.2 / 1.3 / 1.4 / 1.6 / 1.7
GsAF-II (also termed Kappa-theraphotoxin-Gr2c, GsAF-2) was originally isolated from the venom of Grammostola rosea spider. GsAF-II peptide toxin has antinociceptive and antiarrhythmic effects in mammals. The peptide is reported to block the following voltage-gated sodium channels: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with IC50 values of, respectively, 5.7, 12, 24, 4, 6.6 and 1.3 μM. This peptide also blocks hERG1 with an IC50 value of 4.7 μM.
