GsAF-1
GsAF-1 blocks voltage-gated sodium channels
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產(chǎn)品名稱: GsAF-1
GsAF-1 blocks voltage-gated sodium channels
產(chǎn)品型號: 12GSF001-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
GsAF-1
GsAF-1 blocks voltage-gated sodium channels
的詳細介紹
GsAF-1
GsAF-1 blocks voltage-gated sodium channels
GsAF-1 (also termed β-theraphotoxin-Gr1b, GsAF-I) was originally isolated from the venom of Grammostola rosea spider. GsAF-I peptide toxin is reported to block the following voltage-gated sodium channel isoforms: Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6 and Nav1.7 with respective IC50 values of 0.4, 0.6, 1.3, 0.3, 1.2 and 0.04 μM. In addition, the toxin blocks the hERG1 isoform with an IC50 value of 4.8 μM.
