MT7 – Muscarinic Toxin 7
Blocker of M1-subtype of muscarinic receptor
如果您對該產(chǎn)品感興趣的話,可以
產(chǎn)品名稱: MT7 – Muscarinic Toxin 7
Blocker of M1-subtype of muscarinic receptor
產(chǎn)品型號: MTX007-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
MT7 – Muscarinic Toxin 7
Blocker of M1-subtype of muscarinic receptor
的詳細(xì)介紹
MT7 – Muscarinic Toxin 7
Blocker of M1-subtype of muscarinic receptor
Muscarinic toxin 7 (MT7 – m1-toxin 1) has been isolated from the venom of the green mamba (Dendroaspis Angusticeps). MT7 potently blocks M1-subtype of muscarinic acetylcholine receptors at a subnanomolar affintiy. Muscarinic acetylcholine receptors are G-protein coupled receptors that mediate the metabotropic effects of acetylcholine. M1-type muscarinic acetylcholine receptors are well known therapeutic targets to improve cognitive functions in patients with Alzheimer disease. Contrary to many ligands that target mAChRs (pirenzepine, carbamoylcholine chloride, 4-DAMP or atropine), MT7 is the most selective M1-subtype antagonist as it is about 10,000 times more selective for M1-subtype than other subtypes. MT7 toxin is an ideal tool to identify the muscarinic receptor subtype expression in tissues for example. MT7 toxin belongs to the three finger toxin family such as rho-Da1a.
