ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
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產(chǎn)品名稱: ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
產(chǎn)品型號: ADT001-00010
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
的詳細(xì)介紹
ρ-Da1a – AdTx1
Selective antagonist of the alpha(1A)-adrenoceptor
AdTx1 (rho-Da1a – ρ-Da1a) is a 65 amino-acid peptide originally isolated from the venom of the green mamba, an African snake (Dendroaspis angusticep). AdTx1 is stabilized by four disulfide bridges and belongs to the family of the three-finger-fold peptide. AdTx1 has subnanomolar affinity (K(i)= 0.35 nM) and high specificity for the human alpha(1A)-adrenoceptor subtype and is 1000 times more potent on this subtype than on other adrenoceptor subtypes. AdTx1 is a potent relaxant of smooth muscles.
