μ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
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產(chǎn)品名稱: μ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
產(chǎn)品型號: CON021-00100
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
μ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
的詳細介紹
μ-conotoxin-CnIIIC
Selective blocker of Nav1.4 channels
μ-conotoxin CnIIIC is a conopeptide that has been isolated from the venom of the marine cone snail Conus consors. μ-conotoxin CnIIIC exhibits a myorelaxing effect through specific blockade of the skeletal muscle Nav1.4 channels (IC50 = 1.4 nM). μ-conotoxin CnIIIC also blocks Nav1.2 channels (1 μM) and mildly Nav1.7. In contrast, Nav1.5 and Nav1.8 are insensitive to the action of the toxin. μ-conotoxin CnIIIC also blocks the α3β2 nicotinic acetylcholine receptor (IC50= 450 nM) and to lesser extents the α7 and α4β2 subtypes. μ-conotoxin CnIIIC completely inhibits twitch tension in isolated mouse hemidiaphragms (IC50 = 150 nM).
